Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28832612 | 0.95 | GRIN2B (0.40) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL475482 | 0.84 | GRIN2B (0.44) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL28516223 | 0.83 | GRIN2B (0.41) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL28658998 | 0.83 | GRIN2B (0.41) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL6429049 | 0.81 | GRIN2B (0.41) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL4730578 | 0.81 | GRIN2B (0.42) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL12384277 | 0.81 | GRIN2B (0.42) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL8528362 | 0.81 | GRIN2B (0.45) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL28721452 | 0.81 | GRIN2B (0.42) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK | |
| SCHEMBL28119940 | 0.81 | GRIN2B (0.42) | GRIN2BGRIN2CUSP2SMN1; SMN2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112100-A1 | Hepatitis C Virus Inhibitors | PFIZER INC. | 2011-05-12 | — | — | US | disclosed |
| WO-2011004276-A1 | HEPATITIS C VIRUS INHIBITORS | PFIZER LIMITED (GB) | 2011-01-13 | — | — | WO | disclosed |
| EP-1087663-A4 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6514992-B1 | Excessive or inappropriate apoptosis in the neuronal cells occurs in Alzheimer disease and ischemia, T cells in HIV and cardiac myocytes during infarction/reperfusion; caspases inhibit apoptosis | SMITHKLINE BEECHAM CORPORATION | 2003-02-04 | — | — | US | disclosed |
| EP-1087663-A2 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065451-A2 | CASPASES AND APOPTOSIS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112100-A1 | Hepatitis C Virus Inhibitors | HAVCR2, SLC10A1, HCCS | GRIN2B 4795/4885GRIN2C 4446/4885USP2 3010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.