Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4623513 | 0.95 | GRIN2B (0.41) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL3793181 | 0.95 | GRIN2B (0.41) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL475482 | 0.82 | GRIN2B (0.44) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL932957 | 0.81 | GRIN2B (0.43) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL6632443 | 0.80 | GRIN2B (0.46) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL14234512 | 0.80 | GRIN2B (0.46) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL29200802 | 0.80 | GRIN2B (0.43) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL15125135 | 0.80 | GRIN2B (0.46) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL4730578 | 0.79 | GRIN2B (0.42) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 | |
| SCHEMBL28721452 | 0.79 | GRIN2B (0.42) | GRIN2BGRIN2CUSP2SMN1; SMN2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103764641-B | The tricyclic compound of fractional saturation and preparation and application thereof | 扎夫根股份有限公司 | 2016-10-26 | — | — | CN | disclosed |
| CN-1905868-A | DPP-IV inhibitors | GRAFFINITY PHARMACEUTICALS AG (CH) | 2007-01-31 | — | — | CN | disclosed |
| EP-0539281-B1 | Naphthamides, process for their preparation and their application in the therapeutical field | INST NAT SANTE RECH MED (FR) | 1998-12-30 | — | — | EP | disclosed |
| EP-0539281-A1 | New naphthamides, process for their preparation and their application in the therapeutical field | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 1993-04-28 | — | — | EP | disclosed |