SCHEMBL9330592

SCHEMBL9330592

CCOC(=O)c1ccccc1C#Cc1ccc2c(c1)C(C)(C)CC(C)S2

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.44
KMT2A Q03164 3/20 0.44
RARA P10276 2/20 0.44
RARB P10826 2/20 0.44
RARG P13631 2/20 0.44
TSHR P16473 1/20 0.38
CNR2 P34972 1/20 0.35
ALDH1A1 P00352 6/20 0.34
HSD17B10 Q99714 3/20 0.34
LMNA P02545 1/20 0.34
CYP26A1 O43174 1/20 0.34
ADORA3 P0DMS8 2/20 0.33
CDC25B P30305 1/20 0.33
KDM4E B2RXH2 3/20 0.32
HSP90AA1 P07900 1/20 0.32
MAPT P10636 4/20 0.32
OPRM1 P35372 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
PDK2 Q15119 1/20 0.32
ALOX15 P16050 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9331449 0.85 RARB (0.55) CYP3A4KMT2ARARARARBRARG
SCHEMBL9817722 0.83 RARA (0.63) CYP3A4KMT2ARARARARBRARG
SCHEMBL9737688 0.76 RARB (0.39) CYP3A4KMT2ARARARARBRARG
SCHEMBL7163052 0.74 KMT2A (0.42) CYP3A4KMT2ARARARARBRARG
SCHEMBL9817712 0.74 RARA (0.44) CYP3A4KMT2ARARARARBRARG
SCHEMBL9329536 0.74 RARB (0.57) CYP3A4RARARARBRARGCYP26A1
SCHEMBL6365622 0.72 TSHR (0.71) CYP3A4KMT2ATSHRALDH1A1HSD17B10
SCHEMBL9817900 0.72 RARA (0.47) CYP3A4KMT2ARARARARBRARG
SCHEMBL7791411 0.71 TSHR (0.61) CYP3A4KMT2ATSHRALDH1A1HSD17B10
SCHEMBL6368932 0.70 CYP3A4 (0.62) CYP3A4KMT2ARARARARBRARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5278318-A Acetylation under Friedel Crafts condition ALLERGAN, INC. (US) 1994-01-11 US disclosed
EP-0553156-A4 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY 1993-11-18 EP disclosed
EP-0553156-A1 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1993-08-04 EP disclosed
US-5162546-A ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-11-10 US disclosed
WO-1992006084-A1 CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY ALLERGAN, INC. (US) 1992-04-16 WO disclosed