Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.53 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.47 |
| ▸ | CTSD | P07339 | 6/20 | 0.47 |
| ▸ | REN | P00797 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932095 | 0.83 | BACE1 (0.78) | BACE1BACE2CTSDRENKCNH2 | |
| SCHEMBL7862963 | 0.77 | BACE1 (0.60) | BACE1BACE2CTSDRENKCNH2 | |
| SCHEMBL933242 | 0.73 | BACE1 (0.62) | BACE1BACE2CTSDRENKCNH2 | |
| Formic Acid SCHEMBL2283694 | 0.72 | BACE1 (0.54) | BACE1BACE2CTSDRENKCNH2 | |
| SCHEMBL2283698 | 0.71 | BACE1 (0.43) | BACE1BACE2CTSDRENKCNH2 | |
| SCHEMBL931689 | 0.69 | BACE1 (1.00) | BACE1BACE2CTSDRENKCNH2 | |
| SCHEMBL3925005 | 0.68 | BACE1 (0.46) | BACE1BACE2CTSDRENKCNH2 | |
| SCHEMBL20813998 | 0.68 | BACE1 (1.00) | BACE1BACE2CTSD | |
| SCHEMBL13825384 | 0.67 | BACE1 (0.55) | BACE1BACE2CTSDRENKCNH2 | |
| SCHEMBL13825355 | 0.67 | BACE1 (0.64) | BACE1BACE2CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | claimed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |