Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | RRM1 | P23921 | 1/20 | 0.54 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9336088 | 0.90 | TDP1 (0.68) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9336240 | 0.90 | KMT2A (0.53) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9336179 | 0.90 | KMT2A (0.57) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9617041 | 0.88 | KMT2A (0.55) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9336145 | 0.86 | MAPT (0.51) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9333163 | 0.85 | KMT2A (0.52) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2379466 | 0.83 | MAPT (0.80) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL12783890 | 0.81 | MAPT (0.73) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL10448307 | 0.80 | NPC1 (0.60) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL7239674 | 0.80 | RAB9A (0.71) | KMT2AMEN1MAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5302608-A | Antidiabetic, anticholesterol agents; vision disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-12 | — | — | US | claimed |
| EP-0369453-A2 | AGE-formation inhibitory agents | Takeda Chemical Industries, Ltd. (JP) | 1990-05-23 | — | — | EP | claimed |
| JP-3157377-A | — | — | None | — | — | JP | disclosed |
| US-5302608-A | Antidiabetic, anticholesterol agents; vision disorders | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-12 | — | — | US | disclosed |
| JP-H03157377-A | THIOUREA DERIVATIVE AND AGE PRODUCTION INHIBITOR | TAKEDA CHEM IND LTD | 1991-07-05 | — | — | JP | disclosed |
| EP-0369453-A2 | AGE-formation inhibitory agents | Takeda Chemical Industries, Ltd. (JP) | 1990-05-23 | — | — | EP | disclosed |