Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CHRM1CHRM2CHRM3CHRM4ESR1ESR2GABRA1GABRB1GABRG2GBA1HRH1HTR1DHTR2AOPRD1OPRK1OPRM1SLC6A2SLC6A3TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pempidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pempidine SCHEMBL987199 | 0.82 | TSHR (0.69) | TSHRNFKB1CYP2C19FFAR3 | |
| Pempidine SCHEMBL4798468 | 0.76 | TSHR (0.58) | TSHRNFKB1CYP2C19 | |
| Pempidine SCHEMBL217663 | 0.76 | TSHR (0.58) | TSHRNFKB1CYP2C19 | |
| Pempidine SCHEMBL25374670 | 0.75 | TSHR (0.60) | TSHRNFKB1CYP2C19FFAR3SMN1; SMN2 | |
| Pempidine SCHEMBL22408827 | 0.75 | TSHR (0.60) | TSHRNFKB1CYP2C19LMNAFFAR3 | |
| Pempidine SCHEMBL28926027 | 0.74 | TSHR (0.58) | TSHRNFKB1CYP2C19 | |
| Pempidine SCHEMBL988172 | 0.74 | TSHR (0.56) | TSHRNFKB1CYP2C19 | |
| Pempidine SCHEMBL5050688 | 0.74 | TSHR (0.56) | TSHRNFKB1CYP2C19 | |
| Pempidine SCHEMBL17292879 | 0.73 | TSHR (0.57) | TSHRNFKB1CYP2C19 | |
| Pempidine SCHEMBL986676 | 0.73 | TSHR (0.57) | TSHRNFKB1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120030456-A | Data cleaning and fault diagnosis method for traction mechanism of quay crane trolley | 频率探索智能科技江苏有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-120014124-A | Real-time interaction-oriented face feature diversification synthesis self-adaptive digital human system | 联通沃音乐文化有限公司 | 2025-05-16 | — | — | CN | claimed |
| CN-119763665-A | Gene regulation and control network inference method and system based on graph representation learning | 江南大学 | 2025-04-04 | — | — | CN | claimed |
| CN-117935925-A | Antigen-antibody binding affinity prediction method and system based on ensemble learning | 华中科技大学 | 2024-04-26 | — | — | CN | claimed |
| CN-117453669-A | Data recovery method and system for liquid level monitoring sequence | 中国电建集团华东勘测设计研究院有限公司 | 2024-01-26 | — | — | CN | claimed |
| WO-2023229993-A1 | OPHTHALMIC FORMULATION CAPABLE OF DELIVERING METFORMIN TO CHOROID RPE AND RETINA | CURATIVE BIOTECHNOLOGY, INC. (US) | 2023-11-30 | — | — | WO | claimed |
| EP-4027985-A1 | DRUGGABLE TARGET TO TREAT RETINAL DEGENERATION | The United States of America, as represented by The Secretary, Department of Health and Human Services (US) | 2022-07-20 | — | — | EP | claimed |
| WO-2021050980-A1 | DRUGGABLE TARGET TO TREAT RETINAL DEGENERATION | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2021-03-18 | — | — | WO | claimed |
| US-20100029654-A1 | CARDIOVASCULAR COMPOSITIONS AND USE OF THE SAME FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MOUNT SINAI SCHOOL OF MEDICINE | 2010-02-04 | — | — | US | claimed |
| EP-2007385-A2 | CARDIOVASCULAR COMPOSITION AND USE THE SAME FOR THE TREATMENT OF ALZHEIMERS DISEASE | Mount Sinai School of Medicine (US) | 2008-12-31 | — | — | EP | claimed |
| WO-2007112288-A2 | CARDIOVASCULAR COMPOSITION AND USE THE SAME FOR THE TREATMENT OF ALZHEIMERS DISEASE | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2007-10-04 | — | — | WO | claimed |
| US-20040093951-A1 | Magnetoelastic pressure sensor | VISTEON GLOBAL TECHNOLOGIES, INC. | 2004-05-20 | — | — | US | claimed |
| EP-4680243-A1 | METHODS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION | The United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2026-01-21 | — | — | EP | disclosed |
| US-20250339496-A1 | SYSTEMS AND METHODS FOR SYMPATHETIC CARDIOPULMONARY NEUROMODULATION | TULAVI THERAPEUTICS INC (US) | 2025-11-06 | — | — | US | disclosed |
| EP-3288626-B1 | SUBSTANCES AND COMPOSITIONS FOR USE IN BLOCKING NERVE REGENERATION | REFLEX MEDICAL INC (US) | 2025-10-29 | — | — | EP | disclosed |
| US-20250288728-A1 | SYSTEMS AND METHODS FOR GEL-BASED NEUROMODULATION | TULAVI THERAPEUTICS INC (US) | 2025-09-18 | — | — | US | disclosed |
| US-20070043154-A1 | Resin composition excellent in stability to face impact | ASAHI KASEI CHEMICALS CORPORATION (JP) | 2007-02-22 | — | — | US | disclosed |
| EP-1666533-A1 | RESIN COMPOSITION EXCELLENT IN STABILITY TO FACE IMPACT | Asahi Kasei Chemicals Corporation (JP) | 2006-06-07 | — | — | EP | disclosed |
| US-20040093951-A1 | Magnetoelastic pressure sensor | VISTEON GLOBAL TECHNOLOGIES, INC. | 2004-05-20 | — | — | US | disclosed |
| US-4341974-A | Piezoelectric crystal element for use in force, pressure and acceleration transducers | KISTLER INSTRUMENTE AG (CH) | 1982-07-27 | — | — | US | disclosed |