Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932583 | 0.89 | BACE1 (0.44) | BACE1 | |
| Hydrochloric Acid SCHEMBL932779 | 0.88 | BACE1 (0.54) | BACE1 | |
| SCHEMBL968552 | 0.80 | BACE1 (0.60) | BACE1 | |
| SCHEMBL933387 | 0.80 | USP2 (0.34) | — | |
| SCHEMBL6875971 | 0.74 | BACE1 (0.76) | BACE1 | |
| Hydrochloric Acid SCHEMBL967541 | 0.73 | BACE1 (0.75) | BACE1 | |
| Hydrochloric Acid SCHEMBL967542 | 0.73 | BACE1 (0.75) | BACE1 | |
| SCHEMBL3696178 | 0.73 | BACE1 (0.58) | BACE1 | |
| SCHEMBL968820 | 0.71 | BACE1 (0.55) | BACE1 | |
| SCHEMBL2620309 | 0.71 | BACE1 (0.64) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005738-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | WO | disclosed |