SCHEMBL933511

SCHEMBL933511

Cc1ccc([SiH](c2ccc(C)cc2)C2CCCCO2)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.34
NPC1 O15118 6/20 0.34
SMN1; SMN2 Q16637 6/20 0.33
HPGD P15428 3/20 0.33
CYP1A2 P05177 2/20 0.33
CYP2C19 P33261 2/20 0.33
MAPT P10636 2/20 0.33
LMNA P02545 2/20 0.33
TP53 P04637 1/20 0.33
KMT2A Q03164 1/20 0.32
ALDH1A1 P00352 4/20 0.32
NPSR1 Q6W5P4 2/20 0.32
SLC12A2 P55011 1/20 0.32
SLC12A5 Q9H2X9 1/20 0.32
SLC18A3 Q16572 1/20 0.31
TSHR P16473 4/20 0.31
POLB P06746 1/20 0.31
KDM4E B2RXH2 1/20 0.30
GAA P10253 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28380058 0.84 SMN1; SMN2 (0.33) RAB9ANPC1SMN1; SMN2HPGDCYP1A2
SCHEMBL35819 0.81 SMN1; SMN2 (0.36) SMN1; SMN2HPGDLMNAKMT2AALDH1A1
Methane SCHEMBL7528421 0.80 SMN1; SMN2 (0.35) SMN1; SMN2HPGDLMNAKMT2AALDH1A1
SCHEMBL2246994 0.79 NPC1 (0.36) RAB9ANPC1SMN1; SMN2HPGDTP53
SCHEMBL28876704 0.77 SLC6A3 (0.35) SMN1; SMN2HPGDKMT2AALDH1A1GAA
SCHEMBL28108712 0.77 SMN1; SMN2 (0.33) SMN1; SMN2LMNAALDH1A1GAA
Carbon Tetrachloride SCHEMBL28196161 0.76 SMN1; SMN2 (0.33) SMN1; SMN2KMT2AGAA
SCHEMBL1930453 0.74 TP53 (0.42) RAB9ANPC1SMN1; SMN2HPGDMAPT
SCHEMBL7658808 0.71
SCHEMBL7654220 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170333604-A1 READY-MADE BIOMEDICAL DEVICES FOR IN VIVO WELDING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2017-11-23 US disclosed
US-9526813-B2 Intraluminal polymeric devices for the treatment of aneurysms YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2016-12-27 US disclosed
WO-2016075691-A1 READY-MADE BIOMEDICAL DEVICES FOR IN VIVO WELDING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2016-05-19 WO disclosed
US-20120179193-A1 INTRALUMINAL POLYMERIC DEVICES FOR THE TREATMENT OF ANEURYSMS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2012-07-12 US disclosed
EP-2453940-A2 INTRALUMINAL POLYMERIC DEVICES FOR THE TREATMENT OF ANEURYSMS Yissum Research Development Company of The Hebrew University of Jerusalem (IL) 2012-05-23 EP disclosed
WO-2011007352-A2 INTRALUMINAL POLYMERIC DEVICES FOR THE TREATMENT OF ANEURYSMS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2011-01-20 WO disclosed
US-5403898-A Single arm attached cyclodextrin polysiloxanes and use thereof as chiral stationary phases in chromatographic separation of enantiomers BRIGHAM YOUNG UNIVERSITY (US) 1995-04-04 US disclosed
US-5384076-A Resistive film-forming composition and electronic components using the same FUJI XEROX CO., LTD. (JP) 1995-01-24 US disclosed
EP-0240254-A2 Polymerization catalyst, production and use EXXON CHEMICAL PATENTS INC. (US) 1987-10-07 EP disclosed