Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9336253 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| SCHEMBL9336252 | 0.95 | CYP1A2 (0.61) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| SCHEMBL9336264 | 0.95 | CYP1A2 (0.61) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| SCHEMBL9817959 | 0.84 | CYP1A2 (0.63) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| SCHEMBL9337821 | 0.81 | HTT (0.54) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| SCHEMBL9336258 | 0.81 | HTT (0.54) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9336244 | 0.80 | HTT (0.53) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL9336231 | 0.80 | HTT (0.53) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| Timolol SCHEMBL26664858 | 0.78 | CYP1A2 (0.90) | SMN1; SMN2BLMCYP1A2ADRB2ADRB1 | |
| SCHEMBL9339910 | 0.78 | HTT (0.60) | CYP1A2ADRB2ADRB1CYP3A4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283147-B1 | Labile ketone derivatives of 3-substituted-1-alkylamino-2-propanols and their use as beta-adrenergic blockers | UNIV FLORIDA (US) | 1994-05-11 | — | — | EP | disclosed |
| US-5017618-A | Treatment Of Glaucoma | UNIVERSITY OF FLORIDA (US) | 1991-05-21 | — | — | US | disclosed |