Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.84 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.84 |
| ▸ | RARB | P10826 | 14/20 | 0.65 |
| ▸ | RARG | P13631 | 14/20 | 0.65 |
| ▸ | RARA | P10276 | 12/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.51 |
| ▸ | RXRA | P19793 | 5/20 | 0.43 |
| ▸ | RXRB | P28702 | 3/20 | 0.40 |
| ▸ | RXRG | P48443 | 3/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tazarotenic Acid SCHEMBL678713 | 0.92 | CYP3A4 (1.00) | CYP3A4CYP26A1RARBRARGRARA | |
| Tazarotenic Acid SCHEMBL29433140 | 0.92 | CYP3A4 (1.00) | CYP3A4CYP26A1RARBRARGRARA | |
| Tazarotenic Acid SCHEMBL29466098 | 0.92 | CYP3A4 (1.00) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL9333830 | 0.87 | RARB (0.86) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL9007043 | 0.86 | RARB (0.67) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL5084210 | 0.84 | CYP3A4 (0.72) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL6664628 | 0.83 | CYP3A4 (0.71) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL14330777 | 0.83 | CYP3A4 (0.84) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL5482303 | 0.82 | CYP3A4 (0.83) | CYP3A4CYP26A1RARBRARGRARA | |
| SCHEMBL6251130 | 0.81 | CYP3A4 (0.77) | CYP3A4CYP26A1RARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346895-A | Treating dermatoses, immunological disorders, wound healing | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| WO-1992017471-A1 | CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1992-10-15 | — | — | WO | disclosed |