Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 13/20 | 0.86 |
| ▸ | RARA | P10276 | 12/20 | 0.86 |
| ▸ | RARG | P13631 | 10/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.86 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.65 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tazarotene SCHEMBL5747908 | 0.92 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29397163 | 0.92 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL29512592 | 0.92 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL3134 | 0.92 | RARA (1.00) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6101987 | 0.91 | RARA (0.98) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL9007003 | 0.88 | RARB (0.66) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL6841186 | 0.87 | RARB (0.90) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL9270697 | 0.87 | CYP3A4 (0.77) | RARBRARARARGCYP3A4KMT2A | |
| SCHEMBL9337024 | 0.87 | CYP3A4 (0.84) | RARBRARARARGCYP3A4KMT2A | |
| Tazarotene SCHEMBL995330 | 0.87 | RARB (0.88) | RARBRARARARGCYP3A4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346895-A | Treating dermatoses, immunological disorders, wound healing | ALLERGAN, INC. (US) | 1994-09-13 | — | — | US | disclosed |
| EP-0577737-A1 | CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1994-01-12 | — | — | EP | disclosed |
| WO-1992017471-A1 | CHROMANS AND THIOCHROMANS WITH HETEROARYLETHYNYL SUBSTITUENTS AT THE 7-POSITION HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN, INC. (US) | 1992-10-15 | — | — | WO | disclosed |