Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.54 |
| ▸ | CYSLTR2 | Q9NS75 | 7/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GMNN | O75496 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8870891 | 0.85 | CYSLTR1 (0.71) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 | |
| SCHEMBL9387167 | 0.83 | CYSLTR1 (0.56) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL8186157 | 0.79 | CYSLTR1 (0.53) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL9337227 | 0.79 | CYSLTR1 (0.61) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL4449467 | 0.79 | ALOX5AP (0.57) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 | |
| SCHEMBL9337159 | 0.79 | CYSLTR1 (0.54) | CYSLTR1GPBAR1CYSLTR2ALOX5 | |
| SCHEMBL9847398 | 0.75 | CYSLTR1 (0.67) | CYSLTR1GPBAR1CYSLTR2ALOX5MAPK1 | |
| SCHEMBL9339025 | 0.75 | PTGER4 (0.53) | CYSLTR1CYSLTR2ALOX5MAPK1KMT2A | |
| SCHEMBL7460392 | 0.74 | CYSLTR1 (0.51) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6088777 | 0.74 | CYSLTR1 (0.55) | CYSLTR1GPBAR1CYSLTR2MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |