Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9338958 | 1.00 | MAPT (0.42) | MAPTALDH1A1POLBHPGDFBP1 | |
| SCHEMBL9338961 | 1.00 | MAPT (0.42) | MAPTALDH1A1POLBHPGDFBP1 | |
| SCHEMBL9338948 | 1.00 | MAPT (0.42) | MAPTALDH1A1POLBHPGDFBP1 | |
| SCHEMBL9338944 | 1.00 | MAPT (0.42) | MAPTALDH1A1POLBHPGDFBP1 | |
| SCHEMBL5963254 | 0.79 | MAPT (0.42) | MAPTALDH1A1POLBHPGDFBP1 | |
| SCHEMBL5963253 | 0.79 | MAPT (0.42) | MAPTALDH1A1POLBHPGDFBP1 | |
| SCHEMBL9358029 | 0.78 | MAPT (0.41) | MAPTALDH1A1POLBHPGDLMNA | |
| SCHEMBL9789117 | 0.78 | MAPT (0.43) | MAPTALDH1A1POLBHPGDLMNA | |
| SCHEMBL7360682 | 0.78 | ALDH1A1 (0.40) | MAPTALDH1A1POLBHPGDLMNA | |
| SCHEMBL9845163 | 0.78 | MAPT (0.43) | MAPTALDH1A1POLBHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5362902-A | Diuretics and treatment of cardiovascular disorders | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| WO-1991008195-A1 | N-(1-(2-CARBOXYETHYL)CYCLOALKYL CARBONYL)-BETA-ALANINE DERIVATIVES FOR PHARMACEUTICAL USE | PFIZER LIMITED (GB) | 1991-06-13 | — | — | WO | disclosed |