Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATP4A | P20648 | 3/20 | 0.34 |
| ▸ | ATP4B | P51164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339068 | 0.86 | KAT8 (0.44) | KAT8MEN1MAPTKMT2ARAB9A | |
| SCHEMBL9338937 | 0.80 | KAT8 (0.50) | KAT8MEN1MAPTKMT2ARAB9A | |
| SCHEMBL9338942 | 0.80 | KAT8 (0.50) | KAT8MEN1MAPTKMT2ARAB9A | |
| SCHEMBL9339062 | 0.75 | CYSLTR1 (0.38) | PTGS1PTGS2MAPTRAB9ANPC1 | |
| SCHEMBL20298754 | 0.75 | LCK (0.44) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL9531311 | 0.74 | PTGS1 (0.35) | PTGS1PTGS2CYSLTR2CYSLTR1PTGER4 | |
| SCHEMBL9334994 | 0.73 | KAT8 (0.53) | KAT8MEN1MAPTKMT2ARAB9A | |
| SCHEMBL9335002 | 0.73 | KAT8 (0.53) | KAT8MEN1MAPTKMT2ARAB9A | |
| SCHEMBL9335180 | 0.73 | KAT8 (0.50) | KAT8MEN1MAPTKMT2ARAB9A | |
| SCHEMBL9335185 | 0.73 | KAT8 (0.50) | KAT8MEN1MAPTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |