Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 3/20 | 0.75 |
| ▸ | ATIC | P31939 | 1/20 | 0.75 |
| ▸ | DHFR | P00374 | 9/20 | 0.71 |
| ▸ | TYMS | P04818 | 2/20 | 0.61 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.59 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.59 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339217 | 0.99 | GART (0.74) | GARTATICDHFRTYMSFOLR2 | |
| SCHEMBL9343717 | 0.98 | DHFR (0.74) | GARTATICDHFRTYMSFOLR2 | |
| Dideazaacyclotetrahydrofolic Acid SCHEMBL9339115 | 0.94 | GART (0.70) | GARTATICDHFRTYMSFOLR2 | |
| SCHEMBL9339189 | 0.93 | GART (0.69) | GARTATICDHFRTYMSFOLR2 | |
| SCHEMBL9037916 | 0.92 | DHFR (0.69) | GARTATICDHFRTYMSFOLR2 | |
| SCHEMBL9339203 | 0.92 | DHFR (0.69) | GARTATICDHFRTYMSFOLR2 | |
| SCHEMBL9339136 | 0.90 | GART (0.68) | GARTATICDHFRTYMSFOLR2 | |
| SCHEMBL9339198 | 0.87 | GART (0.61) | GARTATICDHFRTYMSFOLR2 | |
| Dideazaacyclotetrahydrofolic Acid SCHEMBL14469101 | 0.86 | GART (1.00) | GARTATICFOLR2FOLR1SLC46A1 | |
| SCHEMBL6647618 | 0.85 | DHFR (0.96) | GARTATICDHFRTYMSFOLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325343-B1 | L-glutamic acid derivatives | UNIV PRINCETON (US) | 1994-06-22 | — | — | EP | disclosed |
| US-4871743-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-10-03 | — | — | US | disclosed |
| EP-0325343-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1989-07-26 | — | — | EP | disclosed |