Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22139858 | 0.78 | HPGD (0.44) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL4231028 | 0.76 | HPGD (0.67) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL9582021 | 0.76 | HPGD (0.47) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL9723032 | 0.76 | HPGD (0.47) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL8507626 | 0.76 | HPGD (0.43) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL25360251 | 0.74 | HPGD (0.35) | HPGDPARP1KDM5BCSNK2A2CSNK2A1 | |
| SCHEMBL9723132 | 0.73 | HPGD (0.41) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL9723069 | 0.73 | HPGD (0.44) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL9339551 | 0.72 | HPGD (0.40) | HPGDPARP1ALDH1A1PIM1PIM3 | |
| SCHEMBL9723036 | 0.72 | HPGD (0.40) | HPGDPARP1ALDH1A1PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0338686-B1 | Pyrimidinone derivatives | ZENECA LTD (GB) | 1994-06-22 | — | — | EP | disclosed |
| US-5149810-A | Chemical intermediates for insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-22 | — | — | US | disclosed |
| US-5077297-A | Insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-31 | — | — | US | disclosed |
| EP-0338686-A2 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1989-10-25 | — | — | EP | disclosed |