Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 7/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9343920 | 0.85 | HPGD (0.62) | HPGDALDH1A1KMT2AHSP90AA1HTT | |
| SCHEMBL16465704 | 0.85 | HPGD (0.73) | HPGDALDH1A1KMT2AHSP90AA1HTT | |
| SCHEMBL16481617 | 0.82 | HPGD (0.69) | HPGDALDH1A1KMT2AHSP90AA1HTT | |
| SCHEMBL9723032 | 0.80 | HPGD (0.47) | HPGDALDH1A1PARP1PIM1PIM3 | |
| SCHEMBL22139858 | 0.78 | HPGD (0.44) | HPGDALDH1A1PARP1PIM1PIM3 | |
| SCHEMBL8507626 | 0.76 | HPGD (0.43) | HPGDALDH1A1PARP1PIM1PIM3 | |
| SCHEMBL9582021 | 0.76 | HPGD (0.47) | HPGDALDH1A1PARP1PIM1PIM3 | |
| SCHEMBL9340305 | 0.76 | HPGD (0.43) | HPGDALDH1A1PARP1PIM1PIM3 | |
| SCHEMBL31710542 | 0.74 | HPGD (0.39) | HPGDKMT2APARP1KDM5BRAB9A | |
| SCHEMBL9723132 | 0.73 | HPGD (0.41) | HPGDALDH1A1PARP1PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114026081-B | Pyridone derivatives as selective cytotoxic agents against HIV-infected cells | 默沙东有限责任公司 | 2025-02-11 | — | — | CN | disclosed |
| EP-3972965-B1 | PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | disclosed |
| EP-3972965-B1 | PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS | MERCK SHARP & DOHME LLC (US) | 2024-07-03 | — | — | EP | disclosed |
| US-20220242847-A1 | PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS | MERCK SHARP & DOHME CORP. (US) | 2022-08-04 | — | — | US | disclosed |
| EP-3972965-A1 | PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS | Merck Sharp & Dohme Corp. (US) | 2022-03-30 | — | — | EP | disclosed |
| EP-3656384-B1 | COMBINATIONS COMPRISING 5-PHENOXY-3H-PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE FOR THE PROPHYLAXIS OR TREATMENT OF INFECTION BY HIV | MERCK SHARP & DOHME (US) | 2022-02-23 | — | — | EP | disclosed |
| EP-3656384-B1 | COMBINATIONS COMPRISING 5-PHENOXY-3H-PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE FOR THE PROPHYLAXIS OR TREATMENT OF INFECTION BY HIV | MERCK SHARP & DOHME (US) | 2022-02-23 | — | — | EP | disclosed |
| CN-114026081-A | Pyridone derivatives as selective cytotoxic agents against HIV-infected cells | 默沙东公司 | 2022-02-08 | — | — | CN | disclosed |
| EP-3785714-A1 | PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-03-03 | — | — | EP | disclosed |
| EP-3785714-A1 | PRODRUGS OF HIV REVERSE TRANSCRIPTASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2007071900-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |
| EP-0338686-B1 | Pyrimidinone derivatives | ZENECA LTD (GB) | 1994-06-22 | — | — | EP | disclosed |
| US-5149810-A | Chemical intermediates for insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-22 | — | — | US | disclosed |
| EP-0481604-A1 | Heterocyclic compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-04-22 | — | — | EP | disclosed |
| US-5104878-A | Insecticides, miticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-04-14 | — | — | US | disclosed |
| US-5077297-A | Insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-12-31 | — | — | US | disclosed |
| US-4990512-A | Insecticides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-02-05 | — | — | US | disclosed |
| EP-0396250-A1 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1990-11-07 | — | — | EP | disclosed |
| EP-0357201-A2 | Pyridyl pyrimidinone derivatives with an insecticidal activity | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-03-07 | — | — | EP | disclosed |
| EP-0338686-A2 | Pyrimidinone derivatives | ZENECA LIMITED (GB) | 1989-10-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220242847-A1 | PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS | PRUNE1, G6PD, ACIN1 | HPGD 458/4885ALDH1A1 1817/4885KMT2A 4612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.