SCHEMBL9340550

SCHEMBL9340550

O=Cc1cc(Cl)c(C(F)(F)F)c(Cl)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 4/20 0.38
TDP1 Q9NUW8 1/20 0.36
ERN1 O75460 5/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9341597 0.84 TDP1 (0.36) NOTUMTDP1ERN1
SCHEMBL9344674 0.76 NOTUM (0.38) NOTUMTDP1
SCHEMBL9342580 0.73 ERN1 (0.34) NOTUMTDP1ERN1
SCHEMBL9628149 0.73 CYP3A4 (0.50) NOTUM
SCHEMBL1312079 0.73 CYP3A4 (0.50) TDP1ERN1
SCHEMBL17341756 0.72 ALDH1A1 (0.46) NOTUMTDP1
SCHEMBL9766847 0.72 NOTUM (0.42) NOTUMTDP1ERN1
SCHEMBL8401591 0.72 ALDH1A1 (0.40) TDP1ERN1
SCHEMBL3620779 0.71 TDP1 (0.39) TDP1ERN1
SCHEMBL7272536 0.69 TDP1 (0.42) NOTUMTDP1ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0396987-B1 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1994-06-15 EP disclosed
US-5041683-A Nuclear-fluorinated trifluoromethylbenzaldehydes BAYER AKTIENGESELLSCHAFT (DE) 1991-08-20 US disclosed
EP-0396987-A2 Nuclear fluorinated trifluoromethylbenzaldehydes BAYER AG (DE) 1990-11-14 EP disclosed