Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339133 | 0.83 | TSHR (0.47) | — | |
| SCHEMBL9339131 | 0.80 | — | — | |
| SCHEMBL9337497 | 0.79 | PPARG (0.56) | AGTR1AGTR2 | |
| SCHEMBL9337200 | 0.77 | TSHR (0.43) | AGTR1 | |
| SCHEMBL9339293 | 0.76 | ATM (0.38) | — | |
| SCHEMBL9337412 | 0.76 | PPARG (0.55) | AGTR1AGTR2 | |
| SCHEMBL9341437 | 0.74 | FFAR1 (0.49) | — | |
| SCHEMBL9337724 | 0.74 | PLK1 (0.62) | AGTR1 | |
| SCHEMBL9402342 | 0.74 | — | — | |
| SCHEMBL16088655 | 0.73 | TRPV1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332750-A | Treatment of hypertension, aldosteronism, cardiac insufficienc y | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-26 | — | — | US | disclosed |
| EP-0530702-A1 | 1,2-dihydro-2-oxopyridines as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |