Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 6/20 | 0.62 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9337028 | 0.90 | PLK1 (0.49) | PLK1PLK3MEN1KMT2AAGTR1 | |
| SCHEMBL9339133 | 0.84 | TSHR (0.47) | PLK1PLK3NPC1RAB9ATRPV1 | |
| SCHEMBL9339096 | 0.83 | AGTR1 (0.54) | MEN1KMT2AAGTR1SMN1; SMN2 | |
| SCHEMBL1464667 | 0.81 | PLK1 (0.90) | PLK1PLK3MEN1KMT2ASLC16A3 | |
| SCHEMBL9532259 | 0.80 | AGTR1 (0.67) | AGTR1 | |
| SCHEMBL9414194 | 0.78 | PLK1 (0.54) | PLK1PLK3MEN1KMT2AAGTR1 | |
| SCHEMBL28808948 | 0.78 | PLK1 (0.97) | PLK1PLK3 | |
| SCHEMBL9337467 | 0.78 | IDH1 (0.45) | — | |
| SCHEMBL9336977 | 0.77 | ESR1 (0.42) | AGTR1 | |
| SCHEMBL8089303 | 0.75 | AGTR2 (0.58) | PLK1PLK3AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332750-A | Treatment of hypertension, aldosteronism, cardiac insufficienc y | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-26 | — | — | US | disclosed |
| EP-0530702-A1 | 1,2-dihydro-2-oxopyridines as angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1993-03-10 | — | — | EP | disclosed |