Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.74 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9341421 | 1.00 | GPR17 (0.74) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL8345217 | 0.92 | GPR17 (0.62) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL9397608 | 0.91 | GPR17 (0.61) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL9397604 | 0.91 | GPR17 (0.61) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL8344673 | 0.88 | GPR17 (0.58) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL9397491 | 0.88 | GPR17 (0.56) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL9397498 | 0.88 | GPR17 (0.56) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| SCHEMBL9395874 | 0.87 | GPR17 (0.56) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| Gavestinel SCHEMBL1721070 | 0.85 | GPR17 (1.00) | GPR17ALOX15KDM4EMEN1ALDH1A1 | |
| Gavestinel SCHEMBL30184856 | 0.85 | GPR17 (1.00) | GPR17ALOX15KDM4EMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6049027-A | — | — | None | — | — | JP | disclosed |
| US-5374648-A | Nervous system disorders | GLAXO S.P.A. (IT) | 1994-12-20 | — | — | US | disclosed |
| US-5373018-A | Antagonist to excitory amino acids on N-methyl aspartic acid receptor complex, theraputically effective in treatment of central nervous system disorder | GLAXO S.P.A. (IT) | 1994-12-13 | — | — | US | disclosed |
| JP-H0649027-A | INDOLE DERIVATIVE | GLAXO SPA | 1994-02-22 | — | — | JP | disclosed |
| EP-0568136-A1 | Indole-2-carboxylic acid derivatives | GLAXO S.p.A. (IT) | 1993-11-03 | — | — | EP | disclosed |