Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9342833 | 0.91 | CHRNA7 (0.43) | CHRNA7 | |
| Oxalic Acid SCHEMBL9710958 | 0.69 | CHRNA7 (0.39) | CHRNA7 | |
| Oxalic Acid SCHEMBL9677370 | 0.69 | CHRNA7 (0.45) | CHRNA7 | |
| Oxalic Acid SCHEMBL9459416 | 0.69 | CHRNA7 (0.39) | CHRNA7 | |
| SCHEMBL20708987 | 0.69 | DPP4 (0.37) | — | |
| Oxalic Acid SCHEMBL7820139 | 0.69 | CHRM2 (0.42) | CHRNA7 | |
| SCHEMBL20704124 | 0.69 | DPP4 (0.33) | — | |
| SCHEMBL4963428 | 0.67 | CHRNA7 (0.44) | CHRNA7 | |
| SCHEMBL18984181 | 0.67 | KDM4E (0.40) | — | |
| SCHEMBL31076291 | 0.67 | KDM4E (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324723-A | Analgesics | MERCK SHARPE & DOHME LTD. | 1994-06-28 | — | — | US | disclosed |
| EP-0307141-B1 | OXAZOLES AND THIAZOLES FOR THE TREATMENT OF SENILE DEMENTIA | MERCK SHARP & DOHME LTD. (GB) | 1993-01-13 | — | — | EP | disclosed |
| EP-0307141-A2 | Oxazoles and thiazoles for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |