Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9451991 | 0.84 | CHRM2 (0.50) | CHRM2CHRM3 | |
| SCHEMBL10433194 | 0.83 | CHRM1 (0.51) | CHRM2CHRM3CHRM1 | |
| SCHEMBL9772068 | 0.74 | CHRM1 (0.44) | CHRM2CHRM3CHRM1 | |
| SCHEMBL9343630 | 0.71 | NPC1 (0.39) | — | |
| SCHEMBL9342146 | 0.71 | CHRM1 (0.53) | CHRM2CHRM3CHRM1 | |
| SCHEMBL7267159 | 0.70 | CDK1 (0.43) | CHRM1 | |
| Hydrochloric Acid SCHEMBL7276876 | 0.70 | CDK1 (0.42) | CHRM1 | |
| SCHEMBL5139637 | 0.69 | CHRM2 (0.55) | CHRM2CHRM3CHRM1 | |
| SCHEMBL8402589 | 0.69 | CHRM2 (0.55) | CHRM2CHRM3CHRM1 | |
| SCHEMBL8404086 | 0.68 | CHRM1 (0.56) | CHRM2CHRM3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324723-A | Analgesics | MERCK SHARPE & DOHME LTD. | 1994-06-28 | — | — | US | claimed |
| EP-0307141-B1 | OXAZOLES AND THIAZOLES FOR THE TREATMENT OF SENILE DEMENTIA | MERCK SHARP & DOHME LTD. (GB) | 1993-01-13 | — | — | EP | claimed |
| EP-0307141-A2 | Oxazoles and thiazoles for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | claimed |
| US-5324723-A | Analgesics | MERCK SHARPE & DOHME LTD. | 1994-06-28 | — | — | US | disclosed |
| EP-0307141-B1 | OXAZOLES AND THIAZOLES FOR THE TREATMENT OF SENILE DEMENTIA | MERCK SHARP & DOHME LTD. (GB) | 1993-01-13 | — | — | EP | disclosed |
| EP-0307141-A2 | Oxazoles and thiazoles for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |