Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.33 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9342071 | 0.91 | CHRM2 (0.43) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9342051 | 0.78 | CHRM3 (0.40) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL9404337 | 0.75 | TSHR (0.38) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL10420362 | 0.72 | CHRM2 (0.59) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL10420357 | 0.72 | CHRM2 (0.59) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL9342817 | 0.72 | TSHR (0.38) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL9404449 | 0.69 | TSHR (0.40) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| SCHEMBL9342139 | 0.69 | CHRM2 (0.38) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL7423063 | 0.69 | BRD4 (0.41) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| SCHEMBL8402426 | 0.67 | CHRM2 (0.46) | CHRM3CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324723-A | Analgesics | MERCK SHARPE & DOHME LTD. | 1994-06-28 | — | — | US | disclosed |
| EP-0307141-B1 | OXAZOLES AND THIAZOLES FOR THE TREATMENT OF SENILE DEMENTIA | MERCK SHARP & DOHME LTD. (GB) | 1993-01-13 | — | — | EP | disclosed |
| EP-0307141-A2 | Oxazoles and thiazoles for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |