Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8403706 | 0.91 | CHRM2 (0.43) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9404477 | 0.80 | CHRM3 (0.39) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL9404365 | 0.79 | CHRM2 (0.51) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9404449 | 0.78 | TSHR (0.40) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL9342137 | 0.75 | TSHR (0.38) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL10420357 | 0.75 | CHRM2 (0.59) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL10420362 | 0.75 | CHRM2 (0.59) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL7423063 | 0.74 | BRD4 (0.41) | TSHRSLC6A1SLC6A13CHRM3CHRM2 | |
| Oxalic Acid SCHEMBL9404484 | 0.74 | POLB (0.36) | TSHRCHRNA4POLBHTTKDM4E | |
| Oxalic Acid SCHEMBL9342051 | 0.69 | CHRM3 (0.40) | TSHRSLC6A1SLC6A13CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5356912-A | 3-(5-isoxazolyl)-1-methyl-1,2,3,6-tetrahydropyridine useful for treating Alzheimer's disease | NOVO NORDISK A/S (DK) | 1994-10-18 | — | — | US | disclosed |
| US-5262427-A | Cognition activators for Alzheimer*s disease | NOVO NORDISK A/S (DK) | 1993-11-16 | — | — | US | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |