SCHEMBL9342176

SCHEMBL9342176

CCSc1ccc(C(=O)C=Cc2cccc(OC)c2OC)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.68
MAOB P27338 4/20 0.65
NFE2L2 Q16236 2/20 0.59
ABCG2 Q9UNQ0 2/20 0.59
NPC1 O15118 3/20 0.57
RAB9A P51151 2/20 0.57
CYP1A2 P05177 2/20 0.55
CYP2D6 P10635 2/20 0.55
CYP1A1 P04798 1/20 0.55
LMNA P02545 3/20 0.55
RELA Q04206 3/20 0.55
ALDH1A1 P00352 1/20 0.55
NTSR1 P30989 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MAPT P10636 2/20 0.53
BCHE P06276 1/20 0.53
CYP3A4 P08684 1/20 0.52
CYP2C9 P11712 1/20 0.52
HPGD P15428 1/20 0.52
CYP2C19 P33261 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9342169 1.00 ALOX5 (0.68) ALOX5MAOBNFE2L2ABCG2NPC1
SCHEMBL9338518 0.89 ABCG2 (0.76) ALOX5MAOBABCG2NPC1RAB9A
SCHEMBL9338506 0.89 ABCG2 (0.76) ALOX5MAOBABCG2NPC1RAB9A
SCHEMBL10498024 0.87 ALOX5 (0.60) ALOX5MAOBNFE2L2ABCG2NPC1
SCHEMBL10497992 0.87 ALOX5 (0.60) ALOX5MAOBNFE2L2ABCG2NPC1
SCHEMBL11296305 0.86 ALOX5 (0.73) ALOX5MAOBNFE2L2ABCG2NPC1
SCHEMBL9338192 0.85 ABCG2 (0.74) ALOX5MAOBABCG2NPC1RAB9A
SCHEMBL9338182 0.85 ABCG2 (0.74) ALOX5MAOBABCG2NPC1RAB9A
SCHEMBL9338014 0.84 ABCG2 (0.55) MAOBABCG2NPC1RAB9ACYP1A1
SCHEMBL9337989 0.84 ABCG2 (0.55) MAOBABCG2NPC1RAB9ACYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0328668-B1 NONLINEAR OPTICAL MATERIAL NIPPON OILS & FATS CO LTD (JP) 1994-05-25 EP disclosed
US-5045239-A Chalcone derivative NIPPON OIL AND FATS CO., LTD. (JP) 1991-09-03 US disclosed
EP-0328668-A1 NONLINEAR OPTICAL MATERIAL NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1989-08-23 EP disclosed
EP-0328669-A1 CHALCONE DERIVATIVE COMPOUNDS NIPPON OIL AND FATS COMPANY, LIMITED (JP) 1989-08-23 EP disclosed