Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 12/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346816 | 0.86 | CNR2 (0.42) | CNR2RAB9ANR5A1CNR1 | |
| SCHEMBL9419334 | 0.84 | RAB9A (0.44) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL9345628 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL9341738 | 0.83 | FEN1 (0.47) | L3MBTL1HTTMAPTRAB9ACASP3 | |
| SCHEMBL9180878 | 0.83 | NR5A1 (0.48) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL9343376 | 0.83 | MAPT (0.49) | KDM4EALDH1A1HPGDHTTCNR2 | |
| SCHEMBL9419317 | 0.83 | RAB9A (0.45) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL27262506 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL27262594 | 0.82 | KDM4E (0.44) | KDM4EALDH1A1HPGDL3MBTL1HTT | |
| SCHEMBL9493519 | 0.82 | CNR2 (0.48) | ALDH1A1CNR2NR5A1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0373191-B1 | HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES | MERCK PATENT GMBH (DE) | 1994-07-13 | — | — | EP | disclosed |
| US-5209866-A | HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-05-11 | — | — | US | disclosed |
| EP-0373191-A1 | HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES. | MERCK PATENT GMBH (DE) | 1990-06-20 | — | — | EP | disclosed |
| WO-1989008649-A1 | HETEROCYCLIC 1,2-DIFLUOROBENZENE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1989-09-21 | — | — | WO | disclosed |
| EP-0332024-A1 | Heterocyclic derivatives of 1,2-difluorobenzene | MERCK PATENT GmbH (DE) | 1989-09-13 | — | — | EP | disclosed |