Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.61 |
| ▸ | HTR2C | P28335 | 5/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.58 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.58 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | CFTR | P13569 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395731 | 0.92 | CFTR (0.70) | RAB9ANPC1SMN1; SMN2GPR55CFTR | |
| SCHEMBL4430677 | 0.82 | CFTR (0.80) | RAB9ANPC1HTR2CHRH3CFTR | |
| SCHEMBL9340089 | 0.81 | SMN1; SMN2 (0.66) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9341641 | 0.81 | NR4A2 (0.72) | RAB9ANPC1SMN1; SMN2HRH3CFTR | |
| SCHEMBL20704909 | 0.80 | CFTR (0.65) | SMN1; SMN2SIRT2SIRT1SIRT3CFTR | |
| SCHEMBL4805762 | 0.79 | MEN1 (0.73) | RAB9ANPC1SMN1; SMN2SIRT2SIRT3 | |
| SCHEMBL28583845 | 0.78 | NHERF1 (0.68) | RAB9ANPC1HTR2CHRH3CFTR | |
| SCHEMBL14096226 | 0.78 | MEN1 (0.60) | RAB9ANPC1SMN1; SMN2HTR2CSIRT2 | |
| SCHEMBL29050153 | 0.78 | CFTR (0.73) | RAB9ANPC1CFTRMEN1KMT2A | |
| SCHEMBL16416919 | 0.78 | SMN1; SMN2 (0.51) | RAB9ANPC1SMN1; SMN2CFTRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598754-A1 | INDOLES | Pfizer Limited (GB) | 1994-06-01 | — | — | EP | disclosed |
| WO-1993002051-A1 | INDOLES | PFIZER LIMITED (GB) | 1993-02-04 | — | — | WO | disclosed |