Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9341414 | 0.81 | KCNH2 (0.48) | KCNH2HTR4DRD4HTR7SLC6A2 | |
| SCHEMBL7383392 | 0.79 | KCNH2 (0.51) | KCNH2DRD4HTR7KDM4E | |
| SCHEMBL9340315 | 0.76 | MEN1 (0.47) | KCNH2HTR4DRD4KDM4E | |
| SCHEMBL8575364 | 0.74 | KCNH2 (0.46) | KCNH2HTR4DRD4 | |
| SCHEMBL9344326 | 0.74 | KCNH2 (0.45) | KCNH2HTR4HTR7SLC6A4 | |
| Hydrochloric Acid SCHEMBL7325637 | 0.74 | KCNH2 (0.45) | KCNH2HTR4DRD4 | |
| SCHEMBL9341292 | 0.73 | KDM4E (0.49) | KCNH2HTR7KDM4E | |
| SCHEMBL9341418 | 0.73 | KCNH2 (0.46) | KCNH2HTR4HTR7SLC6A4 | |
| SCHEMBL9341470 | 0.72 | HTR4 (0.50) | KCNH2HTR4HTR7KDM4E | |
| SCHEMBL6946844 | 0.72 | KCNH2 (0.45) | KCNH2HTR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600955-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993003725-A1 | 5-HT4 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-03-04 | — | — | WO | disclosed |