SCHEMBL9345336

SCHEMBL9345336

CCCC1CCCCC1CCCOc1ccc(C2CCC(C)CC2)cc1

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 12/20 0.47
RAB9A P51151 1/20 0.46
CYP2C9 P11712 4/20 0.46
KCNH2 Q12809 4/20 0.45
CYP3A4 P08684 3/20 0.42
HPGD P15428 1/20 0.40
ESR2 Q92731 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C19 P33261 1/20 0.39
CRBN Q96SW2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9346081 0.95 RAB9A (0.49) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9344365 0.94 RAB9A (0.48) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9346032 0.92 RAB9A (0.47) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9349405 0.92 RAB9A (0.47) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9591046 0.92 HRH3 (0.47) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9346071 0.90 CYP2C9 (0.46) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9349605 0.88 HRH3 (0.45) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9345239 0.88 HRH3 (0.48) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9345183 0.87 HRH3 (0.47) HRH3RAB9ACYP2C9KCNH2CYP3A4
SCHEMBL9346405 0.86 HRH3 (0.43) HRH3RAB9ACYP2C9KCNH2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0344557-B1 Liquid crystal components with a trimethylenoxy group HOFFMANN LA ROCHE (CH) 1994-08-10 EP disclosed
US-5238600-A IBIMETHYLENOXY CONTAINING LIQUID CRYSTAL COMPOUNDS HOFFMANN-LA ROCHE INC. (US) 1993-08-24 US disclosed
EP-0344557-A2 Liquid crystal components with a trimethylenoxy group F. HOFFMANN-LA ROCHE AG (CH) 1989-12-06 EP disclosed