Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | GPX4 | P36969 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 4/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | IAPP | P10997 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9346640 | 1.00 | NPC1 (0.51) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL9350017 | 1.00 | NPC1 (0.51) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL9345427 | 0.98 | ALDH1A1 (0.49) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL9444650 | 0.94 | ALDH1A1 (0.44) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL8626997 | 0.86 | NPC1 (0.47) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL8628171 | 0.86 | NPC1 (0.47) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL8626447 | 0.86 | NPC1 (0.47) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL11367960 | 0.86 | NPC1 (0.64) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL8623275 | 0.83 | SERPINE1 (0.47) | NPC1RAB9APAX8ALDH1A1TP53 | |
| SCHEMBL8624826 | 0.83 | SERPINE1 (0.47) | NPC1RAB9APAX8ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0333522-B1 | Catechol derivatives and pharmaceutical preparations containing same | MITSUI TOATSU CHEMICALS (JP) | 1994-08-17 | — | — | EP | disclosed |
| US-5232923-A | Stimulates production of nerve growth factor; administering for treatment of regressive disorders of the central nervous system | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1993-08-03 | — | — | US | disclosed |
| EP-0333522-A2 | Catechol derivatives and pharmaceutical preparations containing same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-09-20 | — | — | EP | disclosed |