Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 4/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968338 | 0.78 | CYP3A4 (0.39) | CYP1A2PSMB8MAPK14TSHRCYP3A4 | |
| SCHEMBL10367732 | 0.74 | KDM4E (0.39) | CYP1A2MAPK14TSHRCYP3A4LMNA | |
| SCHEMBL5535329 | 0.74 | MAPK14 (0.35) | MAPK14 | |
| SCHEMBL2056254 | 0.74 | MAOB (0.40) | CYP1A2CYP2A6MAPK14 | |
| SCHEMBL31256746 | 0.74 | TDO2 (0.50) | CYP1A2MAPK14TSHRKMT2AL3MBTL1 | |
| Ethane SCHEMBL9369863 | 0.71 | KDM4E (0.38) | CYP1A2MAPK14TSHRKMT2A | |
| SCHEMBL16597607 | 0.70 | — | — | |
| SCHEMBL20778920 | 0.69 | TDO2 (0.37) | MAPK14LMNAMAPTKMT2AL3MBTL1 | |
| SCHEMBL29713452 | 0.69 | HTT (0.44) | CYP2A6PSMB8PSMB5MAPK14TSHR | |
| SCHEMBL31256742 | 0.69 | TDO2 (0.48) | MAPK14TSHRMAPTKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420464-B1 | 3-Isoxazolone derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1994-07-13 | — | — | EP | disclosed |
| US-5321037-A | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants | SANKYO COMPANY, LIMITED (JP) | 1994-06-14 | — | — | US | disclosed |
| EP-0335723-B1 | ISOXAZOLE DERIVATIVES FOR USE AS CEREBRO-ACTIVE DRUGS AND CENTRAL MUSCLE RELAXANTS | Sankyo Company Limited (JP) | 1991-12-04 | — | — | EP | disclosed |
| EP-0420464-A2 | 3-Isoxazolone derivatives, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1991-04-03 | — | — | EP | disclosed |
| EP-0335723-A1 | Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants | Sankyo Company Limited (JP) | 1989-10-04 | — | — | EP | disclosed |
| US-4585472-A | PRE- AND POSTEMERGENCE HERBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1986-04-29 | — | — | US | disclosed |