Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9341869 | 0.89 | CHRM2 (0.41) | CHRM2 | |
| Fumaric Acid SCHEMBL9342821 | 0.72 | CHRNA7 (0.37) | CHRNA7CHRM2 | |
| SCHEMBL9342013 | 0.71 | CHRM2 (0.48) | CHRM2 | |
| Hydrochloric Acid SCHEMBL9342153 | 0.70 | CHRM2 (0.47) | CHRM2 | |
| Oxalic Acid SCHEMBL9724653 | 0.68 | CHRM2 (0.49) | CHRM2 | |
| Maleic Acid SCHEMBL194353 | 0.65 | CHRNA7 (0.39) | CHRNA7 | |
| Maleic Acid SCHEMBL29496245 | 0.65 | CHRNA7 (0.39) | CHRNA7 | |
| Maleic Acid SCHEMBL9854125 | 0.65 | CHRNA7 (0.39) | CHRNA7 | |
| Fumaric Acid SCHEMBL7825260 | 0.64 | CHRM2 (0.53) | CHRM2 | |
| Fumaric Acid SCHEMBL7825256 | 0.64 | CHRM2 (0.53) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5324723-A | Analgesics | MERCK SHARPE & DOHME LTD. | 1994-06-28 | — | — | US | disclosed |
| EP-0307141-B1 | OXAZOLES AND THIAZOLES FOR THE TREATMENT OF SENILE DEMENTIA | MERCK SHARP & DOHME LTD. (GB) | 1993-01-13 | — | — | EP | disclosed |
| EP-0307141-A2 | Oxazoles and thiazoles for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |