Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 5/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.35 |
| ▸ | VDR | P11473 | 2/20 | 0.35 |
| ▸ | OSBP | P22059 | 1/20 | 0.35 |
| ▸ | OSBP2 | Q969R2 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | FGF2 | P09038 | 1/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9348131 | 1.00 | SRD5A2 (0.41) | SRD5A2GPBAR1SRD5A1NPC1L1VDR | |
| SCHEMBL9349226 | 0.91 | SRD5A2 (0.39) | SRD5A2GPBAR1SRD5A1NPC1L1VDR | |
| SCHEMBL9822544 | 0.85 | SRD5A2 (0.47) | SRD5A2GPBAR1SRD5A1NPC1L1VDR | |
| SCHEMBL9822547 | 0.85 | SRD5A2 (0.47) | SRD5A2GPBAR1SRD5A1NPC1L1VDR | |
| SCHEMBL9349187 | 0.84 | SRD5A2 (0.53) | SRD5A2GPBAR1SRD5A1NPC1L1AKR1B10 | |
| SCHEMBL9349191 | 0.84 | SRD5A2 (0.53) | SRD5A2GPBAR1SRD5A1NPC1L1AKR1B10 | |
| SCHEMBL9349181 | 0.84 | SRD5A2 (0.53) | SRD5A2GPBAR1SRD5A1NPC1L1AKR1B10 | |
| SCHEMBL9349319 | 0.82 | SRD5A1 (0.39) | SRD5A2GPBAR1SRD5A1NPC1L1VDR | |
| SCHEMBL9348037 | 0.80 | SRD5A2 (0.51) | SRD5A2GPBAR1SRD5A1NPC1L1VDR | |
| SCHEMBL9782666 | 0.79 | OSBP (0.36) | SRD5A2NPC1L1VDROSBPOSBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375351-B1 | Phosphonic acid substituted steroids as steroid 5alpha-reductase inhibitors | SMITHKLINE BEECHAM CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| US-4946834-A | ACRYLATE ANALOGUES OF STEROIDAL SYNTHETIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-07 | — | — | US | disclosed |