Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 4/20 | 0.47 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.39 |
| ▸ | VDR | P11473 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.37 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9822547 | 1.00 | SRD5A2 (0.47) | SRD5A2GPBAR1VDRCYP2C9HIF1A | |
| SCHEMBL9348135 | 0.85 | SRD5A2 (0.41) | SRD5A2GPBAR1VDRNPC1L1SRD5A1 | |
| SCHEMBL9348131 | 0.85 | SRD5A2 (0.41) | SRD5A2GPBAR1VDRNPC1L1SRD5A1 | |
| SCHEMBL9782678 | 0.85 | SRD5A2 (0.55) | SRD5A2GPBAR1VDRCYP2C9HIF1A | |
| SCHEMBL9782681 | 0.85 | SRD5A2 (0.55) | SRD5A2GPBAR1VDRCYP2C9HIF1A | |
| SCHEMBL9349226 | 0.84 | SRD5A2 (0.39) | SRD5A2GPBAR1VDRCYP2C9HIF1A | |
| SCHEMBL9822617 | 0.83 | SRD5A1 (0.39) | SRD5A2GPBAR1VDRCYP2C9HIF1A | |
| SCHEMBL9822624 | 0.83 | SRD5A1 (0.39) | SRD5A2GPBAR1VDRCYP2C9HIF1A | |
| SCHEMBL9822553 | 0.81 | SRD5A2 (0.59) | SRD5A2GPBAR1VDRCYP2C9HIF1A | |
| SCHEMBL9782796 | 0.81 | SRD5A2 (0.59) | SRD5A2GPBAR1VDRCYP2C9HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289327-B1 | STEROID 5-ALPHA-REDUCTASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-12-18 | — | — | EP | disclosed |
| US-4910226-A | Estrane compound | SMITHKLINE BECKMAN CORPORATION (US) | 1990-03-20 | — | — | US | disclosed |
| EP-0289327-A2 | Steroid 5-alpha-reductase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |