Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.44 |
| ▸ | GSK3A | P49840 | 3/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4129926 | 0.87 | GRM5 (0.48) | DHODHPDE10ARAB9ANPC1GRM5 | |
| SCHEMBL2160345 | 0.83 | PDE10A (0.50) | PDE10A | |
| SCHEMBL3579095 | 0.78 | GRM5 (0.38) | GAAHCAR3SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4141530 | 0.77 | HCAR2 (0.40) | PIM1PDE10AEGFRGRM5 | |
| SCHEMBL4134533 | 0.75 | DHODH (0.62) | PIM1DHODHGSK3BGSK3AGAA | |
| SCHEMBL4907684 | 0.74 | GRM5 (0.49) | PIM1PDE10AGAAHCAR3SMN1; SMN2 | |
| SCHEMBL12100927 | 0.72 | BCL6 (0.49) | GSK3BGSK3AEGFRITKGAA | |
| SCHEMBL29806160 | 0.72 | DHODH (0.44) | PIM1DHODHGSK3BGSK3AEGFR | |
| SCHEMBL22932198 | 0.72 | DHODH (0.44) | PIM1DHODHGSK3BGSK3AEGFR | |
| SCHEMBL29432473 | 0.72 | ALDH1A1 (0.41) | SMN1; SMN2KMT2AMEN1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5350755-A | Treatment of psoriasis or eczema with naphthyridine derivative | SCHERING CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| EP-0144996-B1 | SUBSTITUTED SPIRO PYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS AND COMPOSITIONS | SCHERING CORPORATION (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4775524-A | PSORIASIS | SCHERING CORPORATION (US) | 1988-10-04 | — | — | US | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4652564-A | Substituted spiro pyridine derivatives as anti-allergy and antiinflammatory agents | SCHERING CORPORATION (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0092786-B1 | 1,8-NAPHTHYRIDINE AND 1,5,8-AZANAPHTHYRIDINE DERIVATIVES | SCHERING CORPORATION (US) | 1987-01-07 | — | — | EP | disclosed |
| US-4632923-A | Substituted hetero spiro pyridine derivatives as anti-allergy and anti-inflammatory agents | SCHERING CORPORATION (US) | 1986-12-30 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |
| EP-0092786-A2 | 1,8-Naphthyridine and 1,5,8-azanaphthyridine derivatives | SCHERING CORPORATION (US) | 1983-11-02 | — | — | EP | disclosed |