Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | PAICS | P22234 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2488907 | 0.90 | LPAR1 (0.39) | KDM4EATMMAPTMAPK1LPAR1 | |
| Hydrochloric Acid SCHEMBL544080 | 0.90 | LPAR1 (0.38) | KDM4EATMMAPTMAPK1LPAR1 | |
| Hydrochloric Acid SCHEMBL544865 | 0.90 | LPAR1 (0.38) | KDM4EATMMAPTMAPK1LPAR1 | |
| Hydrochloric Acid SCHEMBL544508 | 0.86 | PAICS (0.37) | KDM4EATMMAPTMAPK1LPAR1 | |
| Hydrochloric Acid SCHEMBL544147 | 0.86 | LPAR1 (0.37) | KDM4EATMMAPTMAPK1LPAR1 | |
| SCHEMBL934611 | 0.85 | KDM4E (0.38) | KDM4EMAPTLPAR1 | |
| SCHEMBL913389 | 0.85 | DGAT2 (0.35) | KDM4EATMMAPTMAPK1LPAR1 | |
| Hydrochloric Acid SCHEMBL913465 | 0.84 | DGAT2 (0.35) | KDM4EATMMAPTMAPK1LPAR1 | |
| Hydrochloric Acid SCHEMBL544409 | 0.84 | LPAR1 (0.40) | KDM4EATMMAPTMAPK1LPAR1 | |
| Hydrochloric Acid SCHEMBL545152 | 0.84 | LPAR1 (0.37) | KDM4EATMMAPTMAPK1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011007090-A1 | DERIVATIVES OF 5,6-BISARYL-2-PYRIMIDINE-CARBOXAMIDE, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS UROTENSIN-II RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2011-01-20 | — | — | WO | claimed |