Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.38 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.38 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9695924 | 0.87 | NPC1 (0.42) | NPC1RAB9AAOC3SYKPARP1 | |
| SCHEMBL9589362 | 0.85 | NPC1 (0.34) | NPC1RAB9AAOC3SMN1; SMN2CASP3 | |
| SCHEMBL1172101 | 0.84 | NPC1 (0.40) | NPC1RAB9AAOC3SMN1; SMN2CASP3 | |
| SCHEMBL9349416 | 0.83 | ALDH1A1 (0.47) | NPC1RAB9AAOC3SMN1; SMN2ALDH1A1 | |
| SCHEMBL12866048 | 0.82 | AOC3 (0.42) | NPC1RAB9AAOC3SMN1; SMN2CASP3 | |
| SCHEMBL9348856 | 0.81 | SMN1; SMN2 (0.41) | NPC1RAB9AAOC3SMN1; SMN2ALDH1A1 | |
| SCHEMBL29625406 | 0.78 | PARP1 (0.54) | NPC1RAB9ASYKPARP1ALDH1A1 | |
| SCHEMBL1720148 | 0.78 | PARP1 (0.54) | NPC1RAB9ASYKPARP1ALDH1A1 | |
| SCHEMBL20241714 | 0.74 | PARP1 (0.43) | NPC1RAB9ASMN1; SMN2PARP1ALDH1A1 | |
| SCHEMBL7853968 | 0.73 | ALDH1A1 (0.44) | NPC1RAB9AAOC3SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401125-B1 | Biphenyl derivatives, process for preparing the same and intermediates therefor | TANABE SEIYAKU CO (JP) | 1994-08-24 | — | — | EP | disclosed |
| US-5233057-A | For treatment or prophylaxis of liver disorders | TANABE SEIYAKU CO., LTD. (JP) | 1993-08-03 | — | — | US | disclosed |
| US-5182404-A | Liver disorders | TANABE SEIYAKE CO., LTD. (JP) | 1993-01-26 | — | — | US | disclosed |
| US-5103023-A | Carboxy derivates with oxy subsitituents for treating liuer disorders | TANABE SEIYAKU CO., LTD. (JP) | 1992-04-07 | — | — | US | disclosed |
| EP-0401125-A2 | Biphenyl derivatives, process for preparing the same and intermediates therefor | TANABE SEIYAKU CO., LTD. (JP) | 1990-12-05 | — | — | EP | disclosed |