Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 18/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 18/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 17/20 | 0.52 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.47 |
| ▸ | PI4KA | P42356 | 2/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.47 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3269567 | 0.86 | PIK3CB (0.69) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 | |
| SCHEMBL925491 | 0.83 | PIK3CB (0.70) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 | |
| Trifluoroacetic Acid SCHEMBL926063 | 0.80 | PIK3CB (0.59) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 | |
| Trifluoroacetic Acid SCHEMBL924671 | 0.78 | PIK3CD (0.64) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 | |
| SCHEMBL924333 | 0.75 | PIK3CB (0.70) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 | |
| SCHEMBL959814 | 0.71 | PIK3CD (0.71) | PIK3CBPIK3CDPIK3CAPIK3CGAKT1 | |
| SCHEMBL927408 | 0.71 | PIK3CB (0.75) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 | |
| SCHEMBL924973 | 0.70 | PIK3CB (1.00) | PIK3CBPIK3CDPIK3CAPIK3CGAKT1 | |
| SCHEMBL926025 | 0.69 | PIK3CB (0.79) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 | |
| SCHEMBL924930 | 0.69 | PIK3CB (0.71) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868188-B2 | 5-heteroaryl thiazoles and their use as PI3K inhibitors | ASTRAZENECA AB (SE) | 2011-01-11 | — | — | US | disclosed |