Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 18/20 | 0.78 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.78 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.78 |
| ▸ | HTR2C | P28335 | 1/20 | 0.78 |
| ▸ | PPARG | P37231 | 1/20 | 0.78 |
| ▸ | HTR2B | P41595 | 1/20 | 0.78 |
| ▸ | PPARD | Q03181 | 1/20 | 0.78 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.78 |
| ▸ | TP53 | P04637 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29464001 | 1.00 | ADORA3 (0.78) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL935807 | 1.00 | ADORA3 (0.78) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL8983111 | 0.89 | ADORA3 (0.75) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL29463995 | 0.89 | ADORA3 (0.77) | ADORA3ADORA1ADORA2AHTR2CHTR2B | |
| SCHEMBL25396739 | 0.88 | ADORA3 (0.73) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| SCHEMBL7287853 | 0.88 | ADORA3 (0.73) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| Namodenoson SCHEMBL1170028 | 0.88 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| Namodenoson SCHEMBL15148066 | 0.88 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| Namodenoson SCHEMBL29376760 | 0.88 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AHTR2CPPARG | |
| Namodenoson SCHEMBL15150531 | 0.88 | ADORA3 (1.00) | ADORA3ADORA1ADORA2AHTR2CPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9668959-B2 | A3 adenosine receptor ligands for modulation of pigmentation | ORADIN PHARMACEUTICAL LTD. (IL) | 2017-06-06 | — | — | US | disclosed |
| EP-2456419-B1 | A3 ADENOSINE RECEPTOR LIGANDS FOR MODULATION OF PIGMENTATION | ORADIN PHARMACEUTICAL LTD (IL) | 2016-11-23 | — | — | EP | disclosed |
| US-20160136079-A1 | A3 ADENOSINE RECEPTOR LIGANDS FOR MODULATION OF PIGMENTATION | ORADIN PHARMACEUTICAL LTD. (IL) | 2016-05-19 | — | — | US | disclosed |
| US-9199102-B2 | A3 adenosine receptor ligands for modulation of pigmentation | ORADIN PHARMACEUTICAL LTD. (IL) | 2015-12-01 | — | — | US | disclosed |
| US-20120134945-A1 | A3 ADENOSINE RECEPTOR LIGANDS FOR MODULATION OF PIGMENTATION | ORADIN PHARMACEUTICAL LTD. (IL) | 2012-05-31 | — | — | US | disclosed |
| EP-2456419-A1 | A3 ADENOSINE RECEPTOR LIGANDS FOR MODULATION OF PIGMENTATION | Oradin Pharmaceutical Ltd. (IL) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011010306-A1 | A3 ADENOSINE RECEPTOR LIGANDS FOR MODULATION OF PIGMENTATION | RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) | 2011-01-27 | — | — | WO | disclosed |