Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3189390 | 0.77 | PDE3B (0.56) | PDE3BPDE3ACYP1A2MAPTALDH1A1 | |
| SCHEMBL3179823 | 0.72 | PDE3B (0.58) | PDE3BPDE3AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL8852559 | 0.69 | DYRK1A (0.53) | MAPTALDH1A1HSD17B10SMN1; SMN2GAA | |
| SCHEMBL4306387 | 0.68 | BACE1 (0.66) | BACE1CYP1A2MAPTALDH1A1HSD17B10 | |
| SCHEMBL18932511 | 0.66 | CA12 (0.46) | PDE3BPDE3ABACE1CA12CA9 | |
| SCHEMBL10813255 | 0.66 | PDE3B (1.00) | PDE3BPDE3A | |
| Medorinone SCHEMBL121782 | 0.65 | PDE3B (1.00) | PDE3BPDE3ACYP1A2MAPTALDH1A1 | |
| SCHEMBL27688255 | 0.65 | PDE3B (0.54) | PDE3BPDE3AALDH1A1SMN1; SMN2GAA | |
| SCHEMBL10727584 | 0.65 | PDE3B (0.53) | PDE3BPDE3ACYP1A2MAPTALDH1A1 | |
| SCHEMBL188316 | 0.65 | MAPK1 (0.43) | PDE3BPDE3ACYP1A2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294620-A | Hypotensive agents or compounds for cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| US-5217976-A | Hypotensive agents, congestive heart failure | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |