Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.59 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9350791 | 0.99 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350645 | 0.99 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350777 | 0.96 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350760 | 0.94 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350644 | 0.88 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9354358 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350633 | 0.83 | KMT2A (0.57) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350699 | 0.81 | SMN1; SMN2 (0.54) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350631 | 0.80 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DADORA2B | |
| SCHEMBL9350672 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | claimed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | claimed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | claimed |
| EP-0369744-B1 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GMBH (DE) | 1994-09-21 | — | — | EP | disclosed |
| US-5321029-A | Vascular and skin disorders; bronchodilator | BEECHAM-WUELFING GMBH & CO.K.G. (DE) | 1994-06-14 | — | — | US | disclosed |
| EP-0369744-A2 | Xanthine derivatives, process for their preparation and pharmaceutical compositions | SMITHKLINE BEECHAM PHARMA GmbH (DE) | 1990-05-23 | — | — | EP | disclosed |