⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3502089 | 0.82 | — | — | |
| SCHEMBL2468575 | 0.77 | — | — | |
| SCHEMBL7704408 | 0.77 | — | — | |
| SCHEMBL7319163 | 0.74 | — | — | |
| SCHEMBL55912 | 0.73 | — | — | |
| SCHEMBL4512521 | 0.71 | — | — | |
| SCHEMBL23765660 | 0.70 | MEN1 (0.38) | — | |
| SCHEMBL19107454 | 0.70 | MEN1 (0.38) | — | |
| SCHEMBL454356 | 0.70 | MEN1 (0.38) | — | |
| SCHEMBL2639323 | 0.70 | MEN1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 273 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220411468-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN-LA ROCHE INC. (US) | 2022-12-29 | — | — | US | claimed |
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2021-04-06 | — | — | US | claimed |
| EP-3267794-B1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2020-09-09 | — | — | EP | claimed |
| EP-3368544-B1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | HOFFMANN LA ROCHE (CH) | 2020-06-17 | — | — | EP | claimed |
| US-20190276425-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2019-09-12 | — | — | US | claimed |
| US-10336721-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2019-07-02 | — | — | US | claimed |
| EP-3368544-A1 | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | H. Hoffnabb-La Roche Ag (CH) | 2018-09-05 | — | — | EP | claimed |
| CN-108350028-A | PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII | 豪夫迈·罗氏有限公司 | 2018-07-31 | — | — | CN | claimed |
| US-10030047-B2 | Peptide macrocycles against acinetobacter baumannii | HOFFMANN-LA ROCHE INC. (US) | 2018-07-24 | — | — | US | claimed |
| US-20180179176-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2018-06-28 | — | — | US | claimed |
| WO-2000059881-A1 | SUBSTITUTED AZETIDIN-2-ONES AS CYSTEINE PROTEASE INHIBITORS | NAEJA PHARMACEUTICAL INC (CA) | 2000-10-12 | — | — | WO | claimed |
| WO-2000047560-A2 | PROCESS FOR THE PREPARATION OF ASYMMETRICAL 1,4-DIHYDRO-PYRIDINE-DICARBOXYLIC ACID ESTERS | EGIS Gyógyszergyár Rt. (HU) | 2000-08-17 | — | — | WO | claimed |
| US-5606066-A | Light activable \"caged\" 1-(2-nitrobenzyl)-substituted 1,4-dihydropyridines | GOLDMANN SIEGFRIED (DE) | 1997-02-25 | — | — | US | claimed |
| EP-0533504-B1 | Dihydropyridine derivatives useful in antitumor therapy | PHARMACIA & UPJOHN SPA (IT) | 1997-02-05 | — | — | EP | claimed |
| EP-0566142-A1 | Inclusion complexes of optically active and racemic 1,4-dihydro pyridines with cyclodextrin derivates | LEK, tovarna farmacevtskih in kemicnih izdelkov, d.d. (SI) | 1993-10-20 | — | — | EP | claimed |
| EP-0533504-A1 | Dihydropyridine derivatives useful in antitumor therapy | PHARMACIA S.p.A. (IT) | 1993-03-24 | — | — | EP | claimed |
| EP-0234517-A1 | Pyrrolo[3,4-b]pyridines, process for their preparation and medicaments containing them for the treatment of vascular diseases | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1987-09-02 | — | — | EP | claimed |
| EP-0225175-A2 | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof | FISONS plc (GB) | 1987-06-10 | — | — | EP | claimed |
| CN-85106878-A | The method for preparing compound | — | 1986-07-23 | — | — | CN | claimed |
| EP-0174131-A2 | Dihydropyridines, processes and intermediates for their production, and pharmaceutical formulations containing them | FISONS plc (GB) | 1986-03-12 | — | — | EP | claimed |