Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | PPARG | P37231 | 8/20 | 0.41 |
| ▸ | PPARA | Q07869 | 8/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354516 | 1.00 | ACE (0.44) | ACESRRHSD17B10CHRM1PPARG | |
| SCHEMBL9354656 | 0.89 | TMEM97 (0.40) | HSD17B10CHRM1PPARGPPARAP2RX7 | |
| SCHEMBL9354661 | 0.89 | TMEM97 (0.40) | HSD17B10CHRM1PPARGPPARAP2RX7 | |
| SCHEMBL7278049 | 0.83 | HSD17B10 (0.58) | ACESRRHSD17B10CHRM1PPARG | |
| SCHEMBL9354821 | 0.83 | HSD17B10 (0.58) | ACESRRHSD17B10CHRM1PPARG | |
| SCHEMBL9354983 | 0.81 | ACE (0.47) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9354973 | 0.81 | ACE (0.47) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9358267 | 0.79 | ACE (0.45) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9358262 | 0.79 | ACE (0.45) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL955547 | 0.78 | MEN1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |