Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | SRR | Q9GZT4 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 13/20 | 0.43 |
| ▸ | PPARA | Q07869 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358267 | 1.00 | ACE (0.45) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9354973 | 0.92 | ACE (0.47) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9354983 | 0.92 | ACE (0.47) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9354726 | 0.88 | CYP2C19 (0.45) | GAA | |
| SCHEMBL9354731 | 0.88 | CYP2C19 (0.45) | GAA | |
| SCHEMBL9740628 | 0.84 | ACE (0.49) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9740620 | 0.84 | ACE (0.49) | ACESRRPPARGPPARAALDH1A1 | |
| SCHEMBL9359097 | 0.84 | SRR (0.51) | ACESRRPPARGPPARAHPGD | |
| SCHEMBL8909660 | 0.84 | SRR (0.51) | ACESRRPPARGPPARAHPGD | |
| SCHEMBL8682156 | 0.84 | SRR (0.51) | ACESRRPPARGPPARAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |