Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.48 |
| ▸ | PREP | P48147 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354523 | 1.00 | SPHK2 (0.52) | SPHK2ACE2CTRB1PREPACE | |
| SCHEMBL9358285 | 1.00 | SPHK2 (0.52) | SPHK2ACE2CTRB1PREPACE | |
| SCHEMBL9354505 | 0.89 | SPHK2 (0.50) | SPHK2ACE2CTRB1ACEATM | |
| SCHEMBL9358849 | 0.89 | SPHK2 (0.50) | SPHK2ACE2CTRB1ACEATM | |
| SCHEMBL9354495 | 0.89 | SPHK2 (0.50) | SPHK2ACE2CTRB1ACEATM | |
| SCHEMBL9358850 | 0.88 | PREP (0.47) | ACE2CTRB1PREPACEATM | |
| SCHEMBL9358845 | 0.88 | PREP (0.47) | ACE2CTRB1PREPACEATM | |
| SCHEMBL809494 | 0.84 | SPHK2 (0.58) | SPHK2ACE2CTRB1PREPL3MBTL1 | |
| SCHEMBL4602602 | 0.84 | SPHK2 (0.58) | SPHK2ACE2CTRB1PREPL3MBTL1 | |
| SCHEMBL5267939 | 0.84 | SPHK2 (0.58) | SPHK2ACE2CTRB1PREPL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |