Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 6/20 | 0.47 |
| ▸ | ACE2 | Q9BYF1 | 3/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9358850 | 1.00 | PREP (0.47) | PREPACE2CTRB1ATML3MBTL1 | |
| SCHEMBL9354968 | 0.89 | ATM (0.45) | PREPACE2ATML3MBTL1ACE | |
| SCHEMBL9354974 | 0.89 | ATM (0.45) | PREPACE2ATML3MBTL1ACE | |
| SCHEMBL9354526 | 0.88 | SPHK2 (0.52) | PREPACE2CTRB1ATML3MBTL1 | |
| SCHEMBL9354523 | 0.88 | SPHK2 (0.52) | PREPACE2CTRB1ATML3MBTL1 | |
| SCHEMBL9358285 | 0.88 | SPHK2 (0.52) | PREPACE2CTRB1ATML3MBTL1 | |
| SCHEMBL13994810 | 0.85 | PREP (0.57) | PREPACE2L3MBTL1NPSR1KDM4E | |
| SCHEMBL791439 | 0.85 | PREP (0.57) | PREPACE2L3MBTL1NPSR1KDM4E | |
| SCHEMBL9354348 | 0.83 | FKBP1A (0.55) | PREPCTRB1L3MBTL1FKBP1ANPSR1 | |
| SCHEMBL9354721 | 0.83 | FKBP1A (0.55) | PREPCTRB1L3MBTL1FKBP1ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| US-5223489-A | Treatment of ypertension and heart failure | UJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-29 | — | — | US | disclosed |
| US-5142048-A | Enzyme inhibitor; carbamoyl group-containing acids | FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) | 1992-08-25 | — | — | US | disclosed |
| US-4921855-A | New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-05-01 | — | — | US | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |