Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.56 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9354935 | 0.93 | KLK7 (0.57) | KLK7TLR2TLR1P2RX7 | |
| SCHEMBL9354881 | 0.90 | KLK7 (0.60) | KLK7TLR2TLR1P2RX7 | |
| SCHEMBL29401167 | 0.81 | KLK7 (0.61) | KLK7TLR2TLR1KMT2AALDH1A1 | |
| SCHEMBL3912355 | 0.81 | KLK7 (0.61) | KLK7TLR2TLR1KMT2AALDH1A1 | |
| SCHEMBL9354399 | 0.79 | MAPK1 (0.58) | KMT2AMAPK1ACEHRH2HRH1 | |
| SCHEMBL9354395 | 0.79 | MAPK1 (0.58) | KMT2AMAPK1ACEHRH2HRH1 | |
| SCHEMBL6163528 | 0.79 | KLK7 (0.56) | KLK7TLR2TLR1P2RX7KMT2A | |
| SCHEMBL7441367 | 0.74 | KLK7 (0.53) | KLK7TLR2TLR1KMT2AALDH1A1 | |
| SCHEMBL3911500 | 0.74 | KLK7 (0.57) | KLK7TLR2TLR1P2RX7ALDH1A1 | |
| SCHEMBL29398857 | 0.73 | KLK7 (0.53) | KLK7TLR2TLR1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0300189-B1 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1994-11-02 | — | — | EP | disclosed |
| EP-0300189-A2 | New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-01-25 | — | — | EP | disclosed |