Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 10/20 | 0.72 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.63 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.63 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL935480 | 1.00 | PRKD1 (0.72) | PRKD1PRKD3PRKD2ERN1SMN1; SMN2 | |
| SCHEMBL938421 | 0.86 | PRKD1 (0.81) | PRKD1PRKD3PRKD2SMN1; SMN2NPC1 | |
| SCHEMBL938420 | 0.86 | PRKD1 (0.81) | PRKD1PRKD3PRKD2SMN1; SMN2NPC1 | |
| SCHEMBL935842 | 0.84 | PRKD1 (0.69) | PRKD1PRKD3PRKD2SMN1; SMN2MAPT | |
| SCHEMBL935620 | 0.83 | PRKD1 (0.68) | PRKD1PRKD3PRKD2SMN1; SMN2MAPT | |
| SCHEMBL935844 | 0.83 | PRKD1 (1.00) | PRKD1PRKD3PRKD2SMN1; SMN2NPC1 | |
| SCHEMBL935619 | 0.83 | PRKD1 (0.68) | PRKD1PRKD3PRKD2SMN1; SMN2MAPT | |
| SCHEMBL935843 | 0.83 | PRKD1 (1.00) | PRKD1PRKD3PRKD2SMN1; SMN2NPC1 | |
| SCHEMBL936381 | 0.82 | PRKD1 (0.77) | PRKD1PRKD3PRKD2SMN1; SMN2NPC1 | |
| SCHEMBL936379 | 0.82 | PRKD1 (0.77) | PRKD1PRKD3PRKD2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |