Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 11/20 | 0.77 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL936379 | 1.00 | PRKD1 (0.77) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL935843 | 0.87 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL935844 | 0.87 | PRKD1 (1.00) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL937700 | 0.85 | PRKD1 (0.54) | PRKD1PRKD3PRKD2NPC1RAB9A | |
| SCHEMBL935842 | 0.84 | PRKD1 (0.69) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL938420 | 0.84 | PRKD1 (0.81) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL938421 | 0.84 | PRKD1 (0.81) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL6922430 | 0.83 | PRKD1 (0.52) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL935481 | 0.82 | PRKD1 (0.72) | PRKD1PRKD3PRKD2ALDH1A1NPC1 | |
| SCHEMBL935480 | 0.82 | PRKD1 (0.72) | PRKD1PRKD3PRKD2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |